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Alvespimycin hydrochloride
CAS No. 467214-21-7
Alvespimycin hydrochloride( 17-DMAG | KOS-1022 | NSC 707545 )
Catalog No. M14563 CAS No. 467214-21-7
A potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 31 | Get Quote |
|
| 10MG | 49 | Get Quote |
|
| 25MG | 88 | Get Quote |
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| 50MG | 156 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAlvespimycin hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.
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DescriptionA potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM; also show comparable binding affinity for Grp94 with EC50 of 65 nM; inhibits the migration and the extracellular matrix-invasiveness of HUVEC in vitro, also inhibits FGF-2 and VEGF-induced HUVEC proliferation and induces apoptosis.Blood Cancer Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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Synonyms17-DMAG | KOS-1022 | NSC 707545
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number467214-21-7
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Formula Weight653.2065
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Molecular FormulaC32H49ClN4O8
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 50 mg/mL
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SMILESNC(O[C@@H](/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC1=C2OCCN(C)C)[C@@H](OC)/C=C\C=C(C)\C(NC(C1=O)=CC2=O)=O)=O.[H]Cl
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Chemical NameGeldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jez JM, et al. Jez JM, 2. Bull EE, et al. Clin Cancer Res. 2004 Dec 1;10(23):8077-84.
3. Kaur G, et al. Clin Cancer Res. 2004 Jul 15;10(14):4813-21.
4. Ge J, et al. J Med Chem. 2006 Jul 27;49(15):4606-15.
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